Orlando Heart Doctors participate in clinical trial of stem cells for heart

Stem cell therapy to improve heart function will be the focus of a human clinical trial. Doctors at Orlando Health Medical Center will participate in the nationwide trial.
By: Florida Spine Center
 
April 16, 2012 - PRLog -- Doctors at Orlando Health Medical Center will participate in a nationwide clinical trial to test whether a patient’s own stem cells can restore tissue and improve heart function after a heart attack.  The PreSERVE-AMI Study is sponsored by Amorcyte LLC, a NeoStem Inc. company.  

Doctors will take patient’s pelvic bone marrow stem cells after a patient has had a stent put in to relieve a STEMI (ST-Segment Elevation Myocardial Infarction), a heart attack caused by a prolonged blockage that causes tissue death in the heart.  In total, 160 patients at 34 locations will be part of the trial.  Some patients will receive placebos.

“Stem cell therapy is part of the movement from treatment to cure and has the potential to overcome limitations and expenses of heart transplants and offers hope for patients who are desperately praying for another chance at life,” said Dr. Vijaykumar Kasi, an interventional cardiologist, the director, Cardiovascular Research, and principal investigator for the clinical trial at OHMC.


Findings of an unrelated stem cell/heart study were presented by doctors from the Texas Heart Institute at St. Luke's Episcopal Hospital at this year’s American College of Cardiology's 61st Annual Scientific Session in Chicago.  They presented the results of a multi-center clinical study that measured the possible benefits of using a patient's own (autologous) bone marrow cells to repair damaged areas of the heart suffering from severe heart failure, a condition that affects millions of Americans.  

The Texas study, involving 92 patients, was conducted at five sites between 2009 and 2011. Patients’ average age was 63 and they were no longer candidates for revascularization, or for surgical treatment.  Each suffered from heart failure and angina (chest pain) and an ejection fraction (the percentage of blood leaving the heart's main pumping chamber, the left ventricle) of less than 45 percent.

Researchers found that left ventricular ejection fraction increased by a small but significant amount (2.7%) in patients who received stem cell therapy.  The study also revealed that younger patients had a higher content of CD34+ and CD133+ cells in their bone marrow and had higher ejection fractions after stem cell treatment.  


According to Dennis Lox, MD, a sports, physical and regenerative medicine specialist in the Tampa Bay area, stem cells appear to hold great promise in treating a variety of diseases and conditions.  Some conditions, such as joint, tendon and muscle injury, are treatable now with stem cells.  Other conditions, such as ALS, diabetes, heart disease and MS, appear to be treatable, but widespread treatment is still in the near-future.

http://www.Drlox.com

Orlando heart trial:
http://www.bizjournals.com/orlando/news/2012/04/11/orland...

Texas heart study:
http://www.texasheart.org/AboutUs/News/2012-03-24news_Per...

Bone marrow vs adipose stem cells for heart treatment:
http://www.reuters.com/article/2012/03/24/us-heart-stemcells-idUSBRE82N09320120324

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Dennis M. Lox, M.D. is board certified in Physical Medicine and Rehabilitation. Since 1990, he has used sports medicine techiques and cutting-edge technology to help heal musculoskeletal injuries and relieve pain.
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Source:Florida Spine Center
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