ICR-1, A New Red-Fluorescent Calcium (Ca²⁺) Indicator With Superior Membrane Permeablilty
ION Calcium Red-1 (ICR-1) is a red-fluorescent (Ex/Em 580 nm/660 nm) calcium (Ca²⁺) indicator for intracellular Ca²⁺ measurements. ICR-1's long-wavelength emission and large Stokes shift reduce contributions of autofluorescence.
ICR-1 is made by ION BIOSCIENCES, San Marcos, Texas.
ICR™ (Ion Calcium Red) is a patent-pending true red-emitting fluorescent calcium indicator, developed by Dr. A Minta, who formerly worked with the late 2009 Nobel Laureate Roger Tsien and co-invented Fluo-1, Fluo-2, Fluo-3 for Calcium, SBFI for Sodium, and PBFI for Potassium.
ICR™ has ideal properties compared to all existing red calcium indicators.
Applications are described in four cell types:
A) MOUSE NEURONS AND ASTROCYTES,
B) STEM CELL-DERIVED CARDIOMYOCYTES,
C) DENTATE GRANULE NEURON,
D) and HEX-293 cells and CHO-K1 cells.
ICR-1 can also be multiplexed with GFP-labeled cells or other green fluorophores commonly used in experiments. Unlike some other red fluorescent Ca²⁺ indicators, ICR-1 does not accumulate in the mitochondria. Data supporting fluorescence lifetime imaging and multiphoton imaging capabilities have also been demonstrated.
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About MoBiTec GmbH
MoBiTec GmbH (Goettingen, Germany) is a privately held company, founded in 1987, that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, magnetic beads for diverse applications, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.
In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.
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