MILPITAS, Calif. -
Sept. 23, 2019 -
PRLog -- Human Carboxylesterase 1 (E.C. 3.1.1.1, CES1, hCE1, CES1b or CES1A1) is a α,β-serine hydrolase expressed in most tissues with higher levels in the liver. It plays a crucial role in the metabolism of various ester xenobiotics including many ester drugs (such as oseltamivir, clopidogrel, irinotecan and capecitabine)
and environmental toxicants (such as pyrethroids)
. Additionally, Carboxylesterases are known to metabolize endogenous esters including triacylglycerols, cholesteryl esters, and other endogenous lipids thereby maintaining lipid homeostasis. More specifically, Carboxylesterases catalyze the ester cleavage of a large number of diverse ester- or amide-containing substrates into alcohol and carboxylic acid. BioVision's Carboxylesterase Activity Assay Kit is a simple, rapid, plate-based fluorometric assay for measuring Carboxylesterase activity in biological samples. The kit uses the proprietary substrate for the quantification of Carboxylesterase (CE) activity in samples. The assay can detect as low as 6.6 µU of Carboxylesterase activity.
Figure: CE Activity in Human Liver Microsomes (HLM, 16 mg/ml), and HepG2 Lysate (3.21 mg/ml). Assay was performed following the kit K2014 protocol.
For more information on this kit, visit:
https://www.biovision.com/carboxylesterase-activity-assay-kit-fluorometric.html
