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Endotoxin Detection kits from Lonza available with us
We are happy to inform the launch of LONZA make Endotoxin Kits(LAL Test)
1) LAL Lysate 0.125 EU/ml Sensitive-16 Tests
2) LAL Lysate 0.125 EU/ml Sensitive-50 Tests
3) LAL Lysate 0.06 EU/ml Sensitive-16 Tests
4) LAL Lysate 0.03 EU/ml Sensitive-50 Tests
6) Endotoxin Challenge Vials
7) Kinetic Turbidimetric Assay
8) Kinetic Chromogenic Assay
9) Incubating UV-VIS Reader For Turbidimetric & Chromogenic Assays
10) Endotoxin Software
Endotoxin free (LAL) Accessories
1) LAL Reagent water (endotoxin free water)-30ml,100ml,500ml
2) Pyrogen Free Tips 20-200ul
3) Pyrogen Free Tips 200-1000ul
4) Pyrogen free assay Tubes-10 x75 mm
5) Pyrogen free Dilution Tubes-13 x 100 mm
6) LAL Reservoirs
7) Pyrogen free Micro Trays
9) Tris Buffer
10) Heating Block
visit us http://www.indradiagnostics.com/
IMPORTANCE OF ENDOTOXIN TESTING IN HEMODIALYSIS PROCEDURE
Uncountable lives of renal disease patients depend on dialysis procedures, many number of patients worldwide undergo maintenance or long-term hemodialysis. The main Challenges in Hemodialysis is to produce large quantity of high purity water cost effectively and the other challenge which requires attention is occurrence of endotoxin related reactions.
Endotoxin: A pyrogenic substance (lipopolysaccharide)
There is mounting evidence to suggest that exposure to relatively low levels of endotoxin causes chronic inflammation and there is increasing evidence linking inflammation to cardiovascular disease in the general public but the effect of inflammation on rates of mortality and morbidity in haemodialysis patients is still under debate. To be certain that the health of patients is not being compromised, dialysis units should aim to minimise their exposure to any detectable level of endotoxin.
Water used for haemodialysis should meet the requirements of the local specifications for purity.(The European Pharmacopoeia says total viable count <100 cfu/ml and endotoxin level =0.25 IU/ml)
Water treatment systems used in dialysis are a critical factor in the overall care received by dialysis patients; they also provide one of the greatest hazards to the patients if they are not functioning properly.
Water used for haemodialysis should be tested routinely to verify the efficacy of the disinfection programme, Disinfection is a less lethal process than sterilization, since it is expected to destroy most recognized pathogenic microorganisms, but not necessarily all those present. Disinfection does not eliminate endotoxin, it is stable, it is not easily destroyed by sanitizers , Only ultra filtration removes endotoxin.
The LAL assay is the method recommended for endotoxin testing by the most Pharmacopoeias, and is widely used the pharmaceutical industry.
All the established techniques (gel-clot, turbidity and chromogenic)
The LAL gel-clot test and Chromogenic Endpoint assay can be performed very easily in a dialysis unit. The suppliers of the LAL reagent will normally provide training in the testing and validation procedures.