Analysis Methods for Residual oxygen and Headspace Gas of Ampoules

Jan. 18, 2011 - PRLog -- Headspace Gas/ Residual Oxygen analysis of Ampoules is one of the most crucial factors that affects quality of powder injections, water injections, infusion bottles, oral liquids etc.

Now, Labthink (www.labthink.cn) provides a convenient and efficient solution for measurement of residual oxygen of small packages, especially ampoules.

1. Significance for Control the Residual Oxygen Volume of Ampoules.

Oxygen is one of the most important factors that affects the quality guarantee period of powder injections, water injections, infusion bottles, or oral liquids, etc. Quality guarantee period could be prolonged by controlling the headspace gas composition. Powder injections, water injections, infusion bottles, and oral liquids, etc., are usually packed in the form of ampoules. The actual gas composition would be deviated from the supposed one due to the fact that small volumes of air would be left as headspace gas after ampoules are filled and sealed.
In this case, it' s not that easy to analyze the product quality, quality guaranteed period, and the rationality of design of the packages.
Headspace analysis has been one important method for assessing package design quality and for checking quality guarantee period of pharmaceuticals. Headspace gas analyzer developed by Labthink offers an effective solution for gas compositional analysis of ampoules.

2. Obstacles for Headspace Gas Analysis of Ampoules

Quantitative measurement of residual oxygen is the key point for headspace gas analysis. The whole ampoule package is small; and correspondingly, the amount of headspace gas of ampoule is even smaller. The common headspace gas testing instruments are unable to test and analyze gas quantity less than 0.5ml or even less than 0.2ml.
Thus, the small gas volume and difficulties to collect gas are the obstacles that prevent headspace gas analysis for small packages, especially ampoules.

3. Selection of a suitable Headspace Gas Analyzer
Common headspace gas testing instruments are unable to measure and evaluate residual oxygen of pharmaceutical packages.

Labthink HGA-01 Headspace Gas Analyzer is equipped with special samplers that solves the above mentioned obstacles and makes it possible to analyze headspace gas of small packages. The instrument combines the advantages of table and portable headspace gas analyzers, and offers excellent performances.

Firstly, it has wide coverage of testing subjects. The instrument can detect content of oxygen (O2) and carbon dioxide (CO2) as well. Thus, the test range and test accuracy is unparalleled.

Secondly, the instrument has several advantages. Labthink engineers have taken different demands of operators into consideration. HGA-01 is portable and equipped with built-in mini-printer, a convenient and easy tool for operators. The instrument features with two sample feed methods, auto and manual; and can test oxygen (O2) and carbon dioxide (CO2) simultaneously. Meanwhile, the instrument has been engineered with special sampling probe, gastight mat and filter that guarantee testing efficiency and testing accuracy. Moreover, reliable gas analysis sensor of world famous brand guarantees more than 6 years' excellent performance, while other headspace gas testing instruments have to change the sensor within 3 or 4 years.

4. Summary for Residual oxygen Analysis of Ampoules.
Residual oxygen analysis of ampoules offers an efficient and accurate way for headspace gas composition control for powder injections, water injections, infusion bottles, and oral liquids, etc. Residual oxygen analysis plays an important role in product quality analysis, quality guarantee period evaluation and package design assessment. Furthermore, residual oxygen analysis of small packages, especially that of ampoule package is crucial for production and QC/QA testing applications.

Labthink HGA-01 Headspace Gas Analyzer, together with its special sampler, offers a practical and reliable testing solution for companies in pharmaceutical and medicine industries.

Further details, do not hesitate to contact us via trade2@labthink.cn, or visit Labthink official website: www.labthink.cn.

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Labthink provide most excellent quality control solutions for pharmaceutical, foodstuff, cosmetics, packaging, printing, adhesive, automotive, petrochemistry, environment, biology, new energy, construction, aviation and electronic industries worldwide.