Investigating if Aspartame Sweetener is a Possible Carcinogen

Learn why the UN IARC/JECFA committee classified aspartame as possibly carcinogenic to humans and what it means.
 
AUSTIN, Texas - July 30, 2023 - PRLog -- IARC/JECFA CLASSIFY ASPARTAME AS A POSSIBLE CARCINOGEN ASSOCIATED WITH HEPATOCELLULAR CARCINOMA, A TYPE OF LIVER CANCER

On July 15, the United Nations agencies IARC (International Agency for Research on Cancer) and JECFA (Joint FAO/WHO Expert Committee on Food Additives) reached a revised assessment of the health safety of the commonly used artificial sweetener aspartame.

The joint IARC/JECFA press release stated, "The working group classified aspartame as possibly carcinogenic to humans (Group 2B) based on limited evidence for cancer in humans (for hepatocellular carcinoma, a type of liver cancer)."

In this Formaspace laboratory report, we will look at how they came to this conclusion and what it means, as well as some important other new warnings the IARC/JECFA issued for other commonly used food additives.

But first, a little context about artificial sweeteners.

Common Natural Sweeteners: Sucrose (Table Sugar), Fructose (Fruit Sugar), And High-Fructose Corn Syrup (HFCS)

Let's start with the sugar compounds that artificial sweeteners seek to replace. These are simple carbohydrates comprised of either one or two types of sugar (e.g. monosaccharides or disaccharides, respectively).

The first is sucrose (commonly known as table sugar), which is typically refined from plants such as sugar cane or sugar beets. As a disaccharide, sucrose contains one glucose and one fructose molecule.

The second is fructose, often called "fruit sugar," which is a monosaccharide (e.g. single type of sugar) found in many fruits, honey, agave, and most root vegetables.

The third commonly available sweetener is high-fructose corn syrup or HFCS. It is a disaccharide, typically comprised of about 55% fructose and 45% glucose.

Finally, our fourth sugar is glucose, which is a monosaccharide (e.g. single type of sugar); this is the body's preferred source of energy (along with fat and protein).

As we digest, sucrose and high-fructose corn syrup are first broken down into their individual components and then metabolized separately. The resulting glucose components can be used by the body right away, but any fructose molecules need to be metabolized first, typically in the liver, where it can also create fat through lipogenesis to store energy.

The body regulates the amount of glucose (commonly referred to as blood sugar) that circulates through the bloodstream through a complex process involving insulin produced in the pancreas. But things can go awry. For example, diabetic patients typically suffer from insulin resistance, preventing them from effectively controlling their blood sugar levels.

Read more...https://formaspace.com/articles/healthcare/investigating-...

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