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Exploring the Cutting-Edge Technology Behind CD19 B Cell Separation
CD19 is a very trustworthy surface biomarker for B cells. Let's take a closer look at its unique cell separation technologies and applications.
CD19 B Cells Used in Research
One of the most promising applications of CD19 B cells is in the development of new therapies for cancer. Researchers have discovered that many cancer cells overexpress the CD19 antigen, making them an attractive target for CD19-specific therapies. One such therapy is the use of chimeric antigen receptor (CAR) T cells, which are modified T cells that are engineered to express a receptor that recognizes and binds to CD19 on cancer cells.
Once the CAR T cells bind to the cancer cells, they destroy them, leading to a reduction in tumor size and improved patient outcomes. CAR T cell therapy has shown remarkable success in treating certain types of leukemia and lymphoma, and ongoing research is exploring its potential use in other types of cancer. CD19 B cells are also being used in research to study the immune response in various medical conditions.
The flow-through can be used to further enrich positive or negative cells because it doesn't have antibody-bound beads in it. One of the best methods for antibody cell separation that doesn't require whole blood preparation is PluriBead. When cells are extracted directly from whole blood, there is very little chance of contamination with unbound cells, especially platelets or erythrocytes. Positive separation is more effective, cheaper, and produces purer results.
PluriBead cell isolation binds specifically to the target cells using specific antibodies. The targeting antibody will "touch" the cells. After isolation using pluristrainers with mesh sizes smaller than the pluribeads, the target cells can be liberated from the beads by cleavage between the pluribead and the antibody. The liquid on top of the mesh can be used for sample preparation and incubation, such as tissue dissociation or the treatment of cells with cell lysis agents (e.g. Buffer RLT, TRIzol).
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