Magnetic Resonance Makes the Invisible Visible

VIENNA - May 18, 2022 - PRLog -- A small group of researchers including Dennis Kurzbach from the Faculty of Chemistry of the University of Vienna just published in „Nature Protocols" an advanced NMR (Nuclear Magnetic Resonance) method to monitor fast and complicated biomolecular events such as protein folding.

For example, protein folding was long considered as one of the great mysteries of modern research. This crucial process during which amino acid chains adopt a 3D structure and functionality, takes place within milliseconds. Being this fast, protein folding events could often not be characterized by NMR spectroscopy; the standard method for studying molecular structures. Employing hyperpolarized water, researchers have now developed a method that dramatically enhances the signals of the proteins, nucleic acids, and other biomolecules. This renders monitoring of processes such as protein folding possible.

Original publication:

Hyperpolarized water as universal sensitivity booster in biomolecular NMR. Christian Hilty, Dennis Kurzbach, Lucio Frydman, Nature Protocols 2022, DOI: 10.1038/s41596-022-00693-8

https://www.nature.com/articles/s41596-022-00693-8

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