Allergy Research: Environment and Climate Shape Regional Patterns of Allergic Sensitization

KREMS, Austria - Dec. 11, 2025 - PRLog -- Allergic sensitization follows distinct regional patterns, and molecular IgE profiling can reveal these profiles in detail. An international research team has now demonstrated both phenomena in a population-based study of 1,000 adults from five cities in Türkiye that represent distinct climate zones. Using high-resolution molecular allergy diagnostics, the researchers identified characteristic regional differences in immunoreactions to allergens by measuring IgE reactivity patterns. The work was co-led by scientists at Karl Landsteiner University (KL Krems) and the Medical University of Vienna, who contributed an allergen microarray that allows simultaneous testing of more than 100 defined molecules. Beyond the specific findings for Türkiye, the study illustrates how molecular allergology can be integrated into population cohorts to characterize regional patterns of allergic sensitization and to develop more context-aware diagnosis, risk assessment and prevention strategies.

Allergic diseases are rising worldwide, but their frequency and clinical presentation vary from region to region, shaped by environmental factors such as climate, vegetation, air quality and lifestyle. Traditional allergy tests are often based on whole allergen extracts and do not reveal which specific molecules trigger a person's IgE response. Molecular allergology fills this gap: by testing specific antibody (IgE) reactivity against individual allergen components, it becomes possible to map sensitization patterns with much finer resolution. The new study applies this approach in a systematic, cross-sectional population survey in Türkiye, a country at the crossroads of Europe, Asia and Africa. Researchers from KL Krems and the Medical University of Vienna, together with partners at Turkish and international centers, designed the project to explore how regional "exposomes" (the sum of all environmental influences) shape IgE profiles – and how this information can support precise allergy care.

https://kris.kl.ac.at/en/publications/molecular-ige-reactivity-profiling-with-micro-arrayed-allergens-r/

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Huey-Jy Huang, PhD

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