- May 20, 2020
-- Molecular Depot is introducing:
Unique donor serum sample with high levels (> 500 ng/mL) of Human Anti-Mouse Antibodies (HAMA). HAMA titer has been established with a validated ELISA method. This serum sample can be used to test HAMA interference in immunoassays.About HAMA
For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay validation.
Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem.
More info about this product at: https://moleculardepot.com/product/high-hama-serum/