NEW ROCHELLE, N.Y. -
Feb. 17, 2015 -
PRLog -- In creating engineered tissues intended to repair or regenerate damaged or diseased human tissues, the goal is to build three-dimensional tissue constructs densely packed with living cells. The Bio-P3, an innovative instrument able to pick up, transport, and assemble multi-cellular microtissues to form larger tissue constructs is described in an article in
Tissue Engineering, Part C: Methods, a peer-reviewed journal from
Mary Ann Liebert, Inc., publishers(http://www.liebertpub.com/)
.The article is available free on the
Tissue Engineering (http://online.liebertpub.com/
doi/full/10.1089/
ten.tec.2014.0439)
website until March 20
th, 2015.
Andrew Blakely, MD, Kali Manning, Anubhav Tripathi, PhD, and
Jeffrey Morgan, PhD, Rhode Island Hospital and Brown University, Providence, RI, developed the manual Bio-P3 device, and in the article "Bio-Pick, Place, and Perfuse: A New Instrument for 3D Tissue Engineering (http://online.liebertpub.com/
doi/full/10.1089/
ten.tec.2014.0439)
," they explain how the device is able to grip, transport, and release multi-cellular microtissues grown in the laboratory, with minimal effects on the viability of the cells or the structure of the microtissue construct. The authors describe the design of the device's gripper and build heads and the peristaltic pump-driven fluid dynamics used to create and maintain contact between the device heads and the microtissues. They discuss applications of the device, the potential for automation, challenges, and future directions.
“This device can be the long-expected breakthrough in the field of regenerative medicine and hopefully allow the fabrication of large 3D organs and tissues," says
John A. Jansen, DDS, PhD, Co-Editor-in-Chief Tissue Engineering, Part C: Methods and Professor and Head of Dentistry, Radboud University Medical Center, The Netherlands.
About the Journal
Tissue Engineering (
http://www.liebertpub.com/ten) is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-
Chief
Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and
Peter C. Johnson, MD, Vice President, Research and Development and Medical Affairs, Vancive Medical Technologies, an Avery Dennison business, and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering.
Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the
Tissue Engineering (http://www.liebertpub.com/
ten) website.
About the Publisher
Mary Ann Liebert, Inc., publishers(
http://www.liebertpub.com/) is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including
Stem Cells and Development, Human Gene Therapy, and
Advances in Wound Care. Its biotechnology trade magazine,
Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the
Mary Ann Liebert, Inc., publishers(http://www.liebertpub.com/)
website.