Peptides International Adds Exciting New Product

Feb. 28, 2011 - PRLog -- Peptides International Inc. is pleased to announce its newest product offering, Maleimide Activated Keyhole Limpet Hemocyanin (mKLH).   Activated KLH  (Keyhole Limpet Hemocyanin) is a popular choice to use as a carrier protein for haptens in order to assist in the activation of an immune response.  Haptens, or small peptides, are often limited by their size and cannot elicit an immune response by themselves.  Activated KLH has a large molecular mass and high immunogenic properties that are ideal for immunogenic stimulation.  Small peptides containing free sulfhydryl groups can react with Maleimide groups of this carrier protein to form stable thioether bonds.  The resulting carrier peptide conjugates can be used to stimulate antibodies for immunization.

Peptides International’s mKLH (product number KLH-6000-PI) offers these features:

Convenient Vialing - Offered in single-use vials of 5 or 10 mg, Maleimide-Activated mKLH is lyophilized and stabilized for easy application, they are cost-effectively priced at $140 and $250, respectively.

Excellent Solubility - Our preparation of mariculture KLH is highly soluble, but if your research requires even greater hydrophilicity and solubility, a PEGylated form can be made available.

Optimized Activation - Specifications require that each lot is activated with > 400 moles of sulfhydryl-reactive maleimide per mole of KLH, ensuring consistently high levels of conjugation.

Sulfhydryl-reactive - Designed for conjugating cysteine-containing peptide antigens to enhance immunogenicity required for high-titer antibody production.

Very Efficient Procedure - Complete the hapten-carrier conjugation reaction in two hours to yield sufficient immunogenicity for several injections and booster immunizations of host animals.

High-Quality Carrier Protein - KLH is isolated from the mollusk Megathura crenulata (keyhole limpet); mKLH is a high-quality form of KLH that is harvested from limpets grown in mariculture.

Highly Immunogenic - KLH has a high molecular mass (0.5 to 13 million daltons; aggregates of 350 and 390kDa subunits) and elicits a stronger immune response than BSA or ovalbumin.

In making the announcement, Dr. Michael Pennington, Chief Technical Officer, stated that, “We at Peptides International are very pleased to offer this new product to the research community and feel very confident that with the tight budgets facing all R & D groups, our attractive pricing, especially in bulk quantities, will maximize the researchers’ results while minimizing their costs.”

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Peptides International Inc. (PEPNET.COM), is a US-based provider of peptide-related catalog products & custom chemistry services specializing in peptides, reagents, building blocks, & enzyme substrates & inhibitors to corporations & research institutions.