Physiologic Instruments' Ussing Chambers Aid Key Cystic Fibrosis Research

VENICE, Fla. - Aug. 14, 2025 - PRLog -- Physiologic Instruments today highlighted the role of its EasyMount® Ussing chamber systems in advancing cystic fibrosis (CF) research. Peer-reviewed studies evaluating CFTR modulators such as ivacaftor, lumacaftor, and the elexacaftor/tezacaftor/ivacaftor combination (ETI) report using EasyMount systems to measure transepithelial ion transport with precision and reproducibility.

"Researchers need clean, reliable currents to make confident calls on CFTR rescue," said David Thompson, Director of Marketing Communications at Physiologic Instruments. "EasyMount provides a stable platform and streamlined workflow, so labs can focus on the biology, not the hardware."

Trusted in Translational Science

• Used with voltage-clamp current measurements in primary airway and nasal epithelial cultures to evaluate CFTR function.
• Cited in European Respiratory Journal, Scientific Reports, and other peer-reviewed studies.
• Supports both pharmacological screening and functional characterization.

Methods Spotlight
In these studies, epithelial monolayers are mounted in EasyMount chambers with custom inserts. The system integrates with Physiologic Instruments' VCC-series voltage-current clamps to record short-circuit current (Isc) under controlled temperature and gas exchange, enabling real-time evaluation of CFTR modulators.

About Physiologic Instruments
Physiologic Instruments designs and manufactures Ussing chambers, voltage-current clamps, and data-acquisition systems for epithelial transport and barrier function research. From teaching labs to translational programs, our EasyMount platform supports high-fidelity electrophysiology in tissues and cell monolayers.
Website: www.physiologicinstruments.com