Research Project to Develop Optogenetic Stem Cell Lines Successful: "Light Switch" for Special Recep

KREMS, Austria - Aug. 13, 2024 - PRLog -- A research project led by the IMC University of Applied Sciences Krems has just been successfully completed and now provides an excellent basis for further projects: The team led by Prof. Christoph Wiesner from the Institute of Biotechnology has succeeded in genetically modifying special receptors (Toll-like receptors, TLRs) on stem cells so that they can be activated by blue light. Such "optogenetic" techniques could be used to precisely control biological signalling pathways in cells, validated them under physiologically relevant conditions and generate disease models. These new optogenetic cell lines will also make a valuable contribution to the understanding of disease mechanisms and the development of innovative, targeted therapeutic approaches.

For several years, the group led by Christoph Wiesner, holder of the "Cellomics / High Content Screening" research professorship at the IMC Krems, has been focusing on optogenetics – an emerging field of research that deals with the targeted control of cells using light. The aim of the project, which has now been successfully completed and was funded by the Austrian Research Promotion Agency (FFG), was to develop new stem cell lines (MSCs, mesenchymal stromal cells) whose receptors have been genetically modified by incorporating light-sensitive proteins so that they can be activated by blue light.

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Institute Biotechnoloy

IMC Krems University of Applied Sciences

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