Crystallization Screen for Protein-DNA Complexes

SAN DIEGO - Oct. 23, 2022 - PRLog -- Crystallization screen consisting of 48 unique crystallization reagents that were proven to be successful in crystallizing protein-DNA complexes. These 48 reagents were formulated after analyzing over 7000 published protein-DNA crystallization conditions and formulating unique reagents that included critical components for the growth of protein-DNA crystals such as the presence of polyamines, PEG of various molecular weights, divalent ions, various salts, reducing agents and other additives.

References Related to Crystallization Screen for Protein-DNA Complexes
  • Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex. Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J. EMBO J. 2018 Jan 17;37(2):282-299.
  • Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC. Science. 2010 Sep 24;329(5999):1663-7.

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