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Several Applications of Canagliflozin
By: Hunan Huateng Pharmaceutical Co. Ltd.
What are the effects of Canagliflozin?
1. Lower blood sugar
As a new type of hypoglycemic drug, Canagliflozin has obvious advantages compared with other drugs. Traditional hypoglycemic drugs keep sugar in the human body, while this type of drug directly excretes sugar through the kidneys, and only when the blood sugar exceeds the kidneys. When the glucose threshold is reached, the hypoglycemic effect is exerted, and the hypoglycemic effect is not stimulated by insulin secretion, so it will not cause the risk of hypoglycemia, so as to achieve the good effect of fast and safe hypoglycemia.
2. Cardiovascular protection
Several studies have shown that SGLT2 inhibitors have cardioprotective effects and can be used in the treatment of heart failure, not only improving patient outcomes, but also reducing hospitalization and mortality, and for heart failure with or without diabetes (https://us.huatengsci.com/
3. Antihypertensive effect
Clinical data show that Canagliflozin can reduce systolic blood pressure to varying degrees, and the reduction is significantly dose-dependent. For example, in the clinical trial of canagliflozin, compared with the placebo group, the reduction in systolic blood pressure was between 2.6-5.7 mmHg at a dose of 100 mg, and at a dose of 300 mg, the reduction in systolic blood pressure reached 3.5-7.9 between mmHg.
4. Weight loss
Canagliflozin reduce energy through the action of urine sugar, and at the same time induce the browning of white adipose tissue. Since there are two main types of fat in humans, namely white fat and brown fat, the former stores energy and the latter produces heat and consumes energy, so brown fat is increased. Quantity can increase energy consumption, improve metabolism, and achieve weight loss.
Huateng Pharma is a leading and professional manufacturer which can provide pharmaceutical intermediates, PEG derivatives, biochemical reagents, APIs, Vitamin D Derivatives and so on. After research and development, Huateng Pharma can provide the following four intermediates of Canagliflozin (https://en.huatengsci.com/
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