“Neurokinin 3 (NK3) Receptor Antagonists - Pipeline Insights, 2015” - A DelveInsight’s Report

NEW DELHI - Aug. 17, 2015 - PRLog -- Neurokinin 3 (NK3) receptor is a GPCR that has been shown to modulate monoaminergic systems within regions of the brain implicated in schizophrenia. The NK3 is one of the neuromodulators receptor family that predominantly expressed in neurons of both the peripheral and central nervous systems. It is particularly involved in many of forebrain areas, such as frontal, parietal, cingulate cortices and basal ganglia structures implicated in psychiatric disease states. The modulators of NK3 receptor activity may have therapeutic utility in psychiatric diseases. Preclinical and Phase II clinical results of osanetant and talnetant in schizophrenic patients have indicated that NK3 antagonists may provide significant improvement of the positive symptoms and cognitive impairment associated with this disorder. Here the discussion of preclinical and clinical evidence that indicates NK3 receptor antagonists might represent a new approach to the treatment of schizophrenia, major depressive disorder, panic attacks and Parkinson's disease.

Currently, the main challenge to move forward a selective NK3 antagonist into the clinic would be to define a safety margin between the desired therapeutic effect and the effect on testosterone levels. The involvement of NKB-NK3 signaling in reproduction in humans may also lead to new exciting indications, such as treatment for sex steroid-sensitive cancers of breast and prostate. At present there are 11+ pipeline drugs with 7+ companies involved in drug development. There are 2 drugs which are in phase II, 1 in phase I, 2 in pre-clinical and 1 in discovery.

DelveInsight, the leading market research and consulting company has added a new report “Neurokinin 3 (NK3) Receptor Antagonists - Pipeline Insights, 2015” to its portfolio. With this launch DelveInsight now has 700+ Reports on Mechanism of Action (MOA) Pipeline Insight. This report provides information on chemical, technology information and comparative analysis at various stages. In addition, it helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage. In addition to this, our research expertise provides our clients with up to date information of market till the date of order.

DelveInsight is offering the Report at a price of USD 1,250 as a single user license, USD 2,500 as a site license and USD 4,000 as a Global/Enterprise License.

For more information on Pipeline Insight Reports, email at info@delveInsight.com

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