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Follow on Google News | Chronic Pain Therapy Research - Activating Glial CellsBy: Arrowhead Publishers In neuropathic pain, glial cells become activated, causing them to release substances that pathologically amplify pain. This new understanding has provided an explanation for the clinical experience that opioids often have pain-promoting side effects. Opioid administration causes glial activation, which paradoxically opposes the pain-modulating effect of opioids. Reversal of the pro-inflammatory activation of glia would thus not only reverse neuropathic pain in general but should also enhance the clinical efficacy of morphine and other opioids Gene therapy treatments for neuropathic pain are a focus of Xalud Therapeutics. The company is developing XT-101, a single administration therapeutic designed to reverse glial activation. XT-101 is an intrathecal therapy that drives the production of the anti-inflammatory cytokine interleukin- For more information on the 7th Annual Pain Therapeutics Summit East on September 25-26, 2013 in Boston please visit: www.paintherapeuticsummiteast.com or for more information on the 7th Annual Pain Therapeutics Summit in San Diego, CA on November 7-8, 2013 please visit: www.paintherapeuticsummit.com End
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