March 6, 2012
-- Researchers from the United States and Canada studied outdated epinephrine autoinjectors to evaluate their ejection volume and the integrity of the dose. Dr. Michael Wein at Florida State University College of Medicine and his colleagues studied the product which is manufactured by Dey Laboratories. Color intensity increased and doses decreased with increasing number of months past expiration date, but solutions < 20 months past expiration date were not discolored and ejected > 90% of doses (0.3 mg or 0.15 mg). The loss of dose ejected was due mainly to decomposition, and potentially relevant in patients with anaphylaxis. Results were published in the February issue of the Journal of Allergy and Clinical Immunology. Outdated Epinephrine Autoinjectors:
Ejection Volume Integrity And Epinephrine Content And Dose K. J. Simons,, O. M. Rachid, M. A. Rawas-Qalaji, M. Wein, Estelle Simons; University of Manitoba, Winnipeg, MB, CANADA, Nova Southeastern University, Fort Lauderdale, FL, 3Florida State University, Tallahassee, FL.
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