Wilson's disease - An Introduction

Aug. 27, 2011 - PRLog -- Wilson's disease is a disease where the patient suffers from collection of Cu-metal in different parts of the anatomy. Copper is accumulated. Common symptoms are seizures and migraines. At docturs.com, we have informative articles discussing the subject. Presented below is a brief discussion.

In an article on docturs.com, John Sandstrom writes about the Wilson’s disease and explains how it is genetic in nature. In reality, it occurs due to the replication and presence of abnormal gene pair. The ATP7B gene forms two copies of the gene which are abnormal. These trigger the collection of copper. Now, such a collection takes place in the brain, liver, and other tissues. The brain and liver are most affected due to which the functioning of the entire body suffers. The characteristic is that is an autosomal recessive mode of inheritance is adopted by the disease and the copper metabolism degenerates.  

The detection and diagnosis of the hepatolenticular degeneration takes place at the clinical level to a large degree, besides the use of the latest technologies which are present today. Serum ceruloplasmin, copper excretion in urine, the presence of Kayser-Fleischer rings around the iris, as well as hepatic copper content are measured for the purpose of diagnosis. Rings near the iris are visibly evident in patients, however, may not be noted in all suffering individuals.

In the body, apart from the heart and liver, the kidneys are also affected as accumulation of the metal beings on inner lining of tissues. Hormonal system is affected and sometimes leads to problems like infertility and habitual abortion.

Traditional methods of treatment include the chelating of the Cu contents with specified agents. The drawback is that the patient may then suffer from side-effects. All the side effects are not known. Nevertheless, advanced research in the filed of medical services, should be able to yield more methodologies based on the understanding of the genotype and phenotype of this specific condition.

The top medical news, latest happenings, detailed discussions can all be accessed on the docturs.com website. As mentioned above, expert author, John Sandstrom has not only discussed the genetics of the Wilson’s disease, but also its symptoms, diagnosis, treatments, history, and Pathophysiology - all in different articles and topics.

The information along with images and medical videos is informative and educative in nature.

For more information visit http://docturs.com/dd/pg/groups/17218/wilsons-disease/ for wilson disease and top medical news.

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