Three-dimensional cell cultures as predictive tools in early drug discovery

LONDON - Jan. 9, 2019 - PRLog -- Based on the recent article from *Drug Target Review, three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur in vivo.

The drug discovery and development pipeline are retooling imaging technologies, such as high content analysis, to accommodate 3D cell cultures as the model of choice.

In a high-content assay, subcellular organelles are analysed by high-resolution images captured by automated microscopes. High content imaging and analysis of 3D cell cultures provides:
• Better predictive information on drug sensitivity
• Improved drug-target validation
• More accurate morphological and functional differentiation

At this year's 3rd Annual 3D Cell Culture Conference, SMi is delighted to have industry experts share their knowledge and discuss 5 key related sessions to the article above:

Stefan Pryzborski, Professor of Cell Technology, University of Durham on Development & application of bioengineering models if human tissues in vitro on

Sally Price, Head of Cell and Translational Science, Medicines Discovery Catapult on 3D Cell Culture in the Advancement of Medicines Discovery

Melanie Matheu, Founder & CEO, Prellis Biologics on The Future of 3D Cell Culture in Medicine: Blending Medical Devices & Cells to Build Organs

*William Mattes, Director, Division of Systems Biology, U.S. Food and Drug Administration on Tools, Not Toys: From Innovation to Regulatory Application
*remote presentation

Michael Raghunath, Head of Center for Cell Biology & Tissue Engineering Director Competence Center TEDD, Zurich University of Applied Sciences on Amplification of Extracelluar Matrix via Macromolecular Crowding in 2D, 3D, Cell Culture and in Bioprinting

If you are interested to learn more about the event or book your place visit http://www.3d-cellculture.com/PR2

We have tailored sponsorship packages still available, if you are interested contact Alia Malick, Director, on +44 (0) 20 827 6168 or email amalick@smi-online.co.uk

For media enquiries, contact Simi Sapal on +44 (0) 20 7827 6000 or ssapal@smi-online.co.uk

3D Cell Culture Conference 2019
20 – 21 February 2019
Copthorne Tara Hotel, London, UK

http://www.3d-cellculture.com/PR2
Follow us @SMiPharm
#SMi3DCellCulture

*https://www.drugtargetreview.com/article/37558/expert-view-three-dimensional-cell-cultures-as-predictive-tools-in-early-drug-discovery/