Functional Proteomics Book Highlights Biotech Support Group's Contributions to the Field

By: Biotech Support Group
MONMOUTH JUNCTION, N.J. - Oct. 27, 2018 - PRLog -- Biotech Support Group reports on a book published by Springer, a global publisher that serves and supports the research community. This book seeks to fill in the current technology gap with a specific collection of technologies developed for the study of protein function at a proteome scale. Written in the Methods in Molecular Biology series format, chapters include introductions, lists of materials and reagents, step-by-step protocols, and tips on troubleshooting and how to interpret results.

The book citation is:

Wang, X. and Kuruc, M., Functional Proteomics – Methods and Protocols, publisher Springer 2018. The link to purchase the book is

In addition to a co-editor role, the efforts of BSG in this book are highlighted in several chapters. First, BSG authors contributed the chapter entitled "Methods to Monitor the Functional Subproteomes of SERPIN Protease Inhibitors". Although SERPINs are found in a variety of functional on/off sub-forms, customarily they are observed and reported in aggregate. As a result, their influence on disease is missed. This chapter ( describes Albumin depletion products AlbuVoid™ and AlbuSorb™ and demonstrates their utility to satisfy investigations of serum SERPINs at a functional level. Link to download chapter (

In another chapter entitled "Making the Case for Functional Proteomics", Perkins describes the research work of BSG stating, "The outcome of their work, differentiation of cancer patients relative to controls, is of general interest for Functional Proteomics with a System Biology context…The analysis of their findings…deemed Stroma Liquid Biopsy, however, goes far beyond creating a simple list of differentiating proteins. Proteins from three interconnected pathways of networks emerged. Further, differentiation is heavily dependent on posttranslational modifications and control mechanisms of those modifications".

Finally, in the chapter entitled "Proteases: Pivot Points in Functional Proteomics, authors Verhamme, Leonard, and Perkins describe BSG's pioneering biomarker efforts in uncovering biological networks, rather than single entities. They write "…for cancer, 'Stroma Liquid Biopsy™' demonstrates a network (or pattern) - based analysis of LC/MS data, connecting multiple networks or pathways that rely profoundly on proteolytic activity (coagulation, complement, and inflammation)…Further, the identified subproteome(s) become a relevant test bed for screening new therapeutics".

"This book represents a large body of our work, and underlies our commitment to all the endeavors of functional proteomics, starting with sample preparation all the way to functional networks. The book supports our belief that proteomic enrichment products are foundational for the functional and structural proteomic analyses necessary to characterize and ultimately to generate useful biomarkers for disease." states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

For more information on Albumin Removal products, visit:

For more information on Stroma Liquid Biopsy™, visit:

About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to

Matthew Kuruc 732-274-2866,

Biotech Support Group LLC
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Location:Monmouth Junction - New Jersey - United States
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