Application Report:AlbuVoid™ & On-Bead Digestion-Tackling The Challenges of Serum Proteomics(LC-MS)

By: Biotech Support Group
biotechsupportgroup_AlbuVoid™ On-Bead Digestion
biotechsupportgroup_AlbuVoid™ On-Bead Digestion
MONMOUTH JUNCTION, N.J. - April 20, 2015 - PRLog -- MONMOUTH JUNCTION, NJ -- Biotech Support Group reports on a new Application Report describing an improved method for on-bead digestion of serum proteins first enriched with AlbuVoid™. The application report is entitled: AlbuVoid™ & On-Bead Digestion: Tackling The Challenges Of Serum Proteomics

The report describes some of the challenges of serum protein abundances and proteolytic resistance which have limited the quantity and quality of serum and plasma proteomic analyses in the past.

The albumin depletion and low abundance protein enrichment combined method described in the report shows how low abundance enrichment integrated with on-bead digestion offers many workflow advantages such as:

·Unique chemically derived beads, it is a consumable, one-time use product with no potential for cross-contamination or reduced performance upon regeneration.

·Species agnostic; human, rat, mouse, goat, sheep, porcine and bovine sera have been tested

·No in-gel digests, no solution digests, no C18 desalting, more consistent, reproducible results

·Compatibility with quantitative label (i.e., iTRAQ) and label-free LC-MS methods

The report can be downloaded from the company website at:

AlbuVoid™ & On-Bead Digestion: Tackling The Challenges Of Serum Proteomics (

“We are pleased with these developments as now our users can get Albumin depletion and digestion in one seamless workflow. With these improved and efficient on-bead methods, digestion of serum and plasma samples will become more robust and reproducible. This method can be applied for discovery proteomics, and either label or label-free quantitation.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

About Biotech Support Group LLC
Biotech Support Group LLC is a leading provider of proteomic, metabolomic and genomic sample preparation and enrichment products and services. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ for nucleic acid isolation. For more information, go to

Dr. Swapan Roy & Matthew Kuruc
Biotech Support Group LLC
1 Deer Park Drive, Suite M
Monmouth Junction NJ 08852
732-274-2866 Worldwide
800-935-0628 North America

Biotech Support Group
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Tags:Albumin Depletion, Itraq, Chromatography, Bead Proteomics, Magnetic Beads
Industry:Biotech, Medical
Location:Monmouth Junction - New Jersey - United States
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