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Follow on Google News |  Tocomin®SupraBio™ Boosts Immune Response In HumanTocomin®SupraBio™ bioenhanced palm tocotrienol complex is effective in enhancing immune function in healthy women
By: CarotechInc Published in the European Journal of Clinical Nutrition, researchers at the Malaysian Palm Oil Board, International Medical University and University Putra Malaysia conducted this randomized, double-blind, placebo-controlled human trial to evaluate potential effects of palm tocotrienol complex during immunization. A total of 108 healthy non-smoking women aged between 18 and 25 years were recruited for this study. Randomly assigned to 2 groups, volunteers in the supplemented group were given 2 x 200 mg of palm tocotrienol complex and for control group, 2 x 200 mg of soy oil (placebo) capsules per day for 2 months. The palm tocotrienol capsules were manufactured by Hovid Berhad and contain Tocomin®SupraBio™ Blood samples were taken and analyzed at 0, 28 and 56 days. On Day 28, these volunteers received a single shot of tetanus toxoid (TT) vaccine after their blood was drawn. Subsequent blood test done at the end of the study period (56 day) revealed that levels of anti-TT antibody, interferon (IFN)-gamma and interleukin (IL)-4 in the supplemented group were significantly elevated post vaccination compared to control. Increased production of IFN-gamma and IL-4 indicates a positive cell-mediated immune response leading to much higher concentration of anti-TT IgG Antibody. At the same time, production of pro-inflammatory marker interleukin (IL)-6 in the supplemented group was significantly suppressed compared to control. In addition, the researchers also documented significantly increased plasma levels of tocotrienol (T3) isomers in the supplemented group compared with controls on days 28 and 56. The concentration of T3 isomers found in the plasma is alpha-T3 > gamma-T3 > delta-T3. This result once again confirms the previous published observation that alpha-tocotrienol has the highest absolute oral bioavailability, followed by gamma-tocotrienol. Delta-tocotrienol has the lowest bioavailability. “This randomized, double-blinded, placebo-controlled clinical trial shows that the bioenhanced palm tocotrienol complex from Tocomin®SupraBio™ “We are exceedingly pleased to know that Tocomin®SupraBio™ Source: D Mahalingam, AK Radhakrishnan, Z Amom, N Ibrahim and K Nesaretnam, “Effects of supplementation with tocotrienol- About Carotech Inc. Carotech, incorporated in 1990, is a public listed company in Malaysia (ACE Market). It was the first producer in the world of natural full spectrum tocotrienol/ Besides being the largest producer of tocotrienol, Carotech is also the only GMP-Certified tocotrienol producer in the world. Tocomin®SupraBio™ Carotech is a subsidiary of Hovid Ltd (www.hovid.com) Carotech manufactures these products under the tradenames: Tocomin®, Tocomin®SupraBio™ Websites: www.carotech.net and www.tocotrienol.org Contacts: Mr. Bryan See, Regional Product Manager, Carotech Inc, USA. Tel: +1(732) 906 1901 E-mail : klsee@carotech.net Dr Sharon Ling, Vice President, Scientific Affairs, Europe Sales and Marketing. Tel : +44 (0) 1296 623 214 E-mail : sling@carotech.net Mr WH Leong, Vice President, Carotech Pty. Ltd (Australia). Tel : +61 (03) 98013881 E-mail : carot3@aol.com # # # Carotech is the only GMP-certified and largest producer of natural tocotrienol (Tocomin) and mixed carotene (Caromin) in the world. Tocomin contains all four tocotrienol isomers with the highest level of alpha, gamma and delta-tocotrienol. End
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