New Report Analyses Possibilities in Drug Delivery to Central Nervous System Diseases

Nov. 10, 2009 - PRLog -- Piribo, the online destination for business intelligence for the biotech and pharmaceutical industry, has added a new report analysing drug delivery in central nervous system diseases.

The report “Drug Delivery in Central Nervous System Diseases: Technologies, Markets and Companies”, reports that the delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders.

The report shows that advances in understanding of the cell biology of the Blood-Brain Barrier (BBB) have opened new avenues and possibilities for improved drug delivery to the CNS.

Several carrier or transport systems, enzymes, and receptors that control the penetration of molecules have been identified in the BBB endothelium. Receptor-mediated transcytosis can transport peptides and proteins across the BBB. Moreover, methods are available to assess the BBB permeability of drugs at the discovery stage to avoid development of drugs that fail to reach their target site of action in the CNS.

Authors of the report note that various strategies that have been used for manipulating the BBB for drug delivery to the brain include osmotic and chemical opening of the blood-brain barrier as well as the use of transport/carrier systems. Other strategies for drug delivery to the brain involve bypassing the BBB.

Furthermore, many of the new developments in the treatment of neurological disorders will be biological therapies and these will require innovative methods for delivery. Cell, gene and antisense therapies are not only innovative treatments for CNS disorders but also involve sophisticated delivery methods.

Profiles of 71 companies involved in drug delivery for CNS disorders are presented along with their technologies, products and 66 collaborations. These include pharmaceutical companies that develop CNS drugs and biotechnology companies that provide technologies for drug delivery. A number of cell and gene therapy companies with products in development for CNS disorders are included. References contains over 400 publications that are cited in the report. The report is supplemented with 50 tables and 9 figures.

The report “Drug Delivery in Central Nervous System Diseases: Technologies,Markets and Companies” is available from Report Buyer http://www.piribo.com/publications/drug_delivery/drug_del...

Piribo product ID: JAI00031

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About Piribo.
Piribo (http://www.piribo.com/publications/drug_delivery/index.html) is a UK-based independent online store supplying business information on the pharmaceutical and biotechnology industries. The website now carries over 17,000 English language titles including, market reports, studies and books and is the UK’s largest online biopharma information store. Subscribers receive a free monthly newsletter and email alerts on new titles in their areas of interest. The company was established in 2004.