“sparkV10 is an exciting and powerful way of generating novel and diverse structures. We are delighted that ProMining, an early-stage biopharmaceutical research and development company, has chosen to work with sparkV10 for the development of small molecule drugs,” says Dr David Bardsley, Cresset’s Sales Director.
Dr Boaz Inbal, CTO at ProMining Therapeutics Ltd. says, “We are excited about using sparkV10 for hit-to-lead optimization purposes in our oncology project. We believe that sparkV10 will guide us through several optimization challenges. As a result, we will be able to better understand the behaviour of several chemical groups in the context of our hit scaffold and to test some required replacement hypotheses.”
Dr Bardsley adds, “Cresset’s software works at the meeting point of chemistry and biology, giving chemists a way of understanding their molecules in terms of biological activity. Cresset’s technology and services are providing companies with the right information, wherever they sit in the drug design workflow.”
Medicinal and computational chemists use sparkV10 to generate novel and diverse active compounds by replacing sections of existing molecules with bioisosteric fragments. The results are used to create or improve IP positions and optimize leads while minimizing ADME and toxicity issues. sparkV10 is available for deployment on standard desktop computers and can be integrated into workflow technologies. sparkV10 will:-
Generate highly innovative ideas for lead molecules in new areas of chemical space, overcoming the ‘chemotype trap’.
Grow fragments to generate novel, drug-like molecules.
Filter results to find the bioisostere with the right mix of physicochemical properties and biological activity.
Tailor results by selecting the chemistry allowed for the replacement moieties.
Display results in detail side-by-side and cluster similar chemical scaffolds.
Search for moieties from real, published or unexplored compound databases or create custom databases based on proprietary chemistry.
For further information on the complete range of software and services available from Cresset, please visit www.cresset-