Acute preoperative exhaustive exercise leads to a "physiologic stress response," which is characterized by increases in reactive hyperemia and peripheral circulating endothelial progenitor cells (EPCs). An impaired response to this physiologic stressor was associated with a higher incidence of postoperative complications in a study that received the Best Clinical Abstract award here at the American Society of Anesthesiologists 2011 Annual Meeting.
"The identification of such nonresponders may improve preoperative risk stratification and allow for strategies that would reduce postoperative complications,"
The release of EPCs into the peripheral circulation is a critical component of the regenerative process after tissue injury. The inability to release EPCs from the bone marrow correlates with poorer survival after critical illnesses, such as sepsis, he pointed out.
Read more: http://www.physioblasts.org/