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Follow on Google News | AROG Pharmaceutical to Present Data on the Activity of Crenolanib Against Mutant PDGFR at ASCOAROG Pharmaceuticals, LLC Announces Presentation of Data on the Activity of Crenolanib Against Mutant PDGFR at 47th American Society of Clinical Oncology Annual Meeting
The data that will be presented at ASCO continue to support the unique activity of crenolanib against D842V, an activating mutation of PDGFRA that is found in a subset of patients with gastrointestinal stromal tumors (GISTs). “GISTs with the PDGFRA D842V mutation are clinically resistant to treatment with the currently approved drugs including imatinib and sunitinib” said Dr. Michael Heinrich (Portland VA Medical Center, OHSU Knight Cancer Institute), principal author of the study. “Crenolanib could be a valuable treatment option for these patients if this activity is confirmed in the on-going clinical trial.” Presentation Details: “The Effect Of Crenolanib (CP-868,596) • Dr. Michael Heinrich, Portland VA Medical Center, OHSU Knight Cancer Institute • Abstract # 10012 • Session: • Saturday, 4 June 2011 • Poster presentation: • Poster discussion: 12:00pm – 1:00pm (McCormick Place E354b) About Crenolanib Crenolanib is a potent and selective inhibitor of platelet derived growth factor receptors (PDGFR), particularly mutant PDGFRα. AROG is investigating the activity of crenolanib against various cancers including GISTs, gliomas, lung and ovarian cancers for tumors that have either amplification, over-expression or mutations of PDGFRα. AROG is conducting a Phase II trial in GIST patients with the D842V mutation in the PDGFRA gene (NCT01243346; About AROG Pharmaceuticals, LLC AROG is a private, oncology-focused biopharmaceutical company based in Dallas, TX. AROG’s mission is to develop novel anticancer drugs for the treatment of rare cancers with significant unmet medical need. To learn more about AROG, please visit www.arogpharma.com. # # # AROG is committed to the development of promising cancer drugs that may broaden treatment options in areas of unmet therapeutic needs. End
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