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Follow on Google News | Now Available: Preclinical Models: Innovative solutions to accelerate drug discovery and developmentNew Pharmaceuticals market report from Business Insights: "Preclinical Models: Innovative solutions to accelerate drug discovery and development"
For more information or to purchase this report, go to: - http://www.fastmr.com/ Partial Table of Contents: Preclinical models Executive summary 10 Preclinical models in drug discovery and development 10 In vivo models in preclinical research 11 In vitro models in preclinical research 12 In silico models in preclinical research 13 Systems biology models in drug discovery 14 Chapter 1 Preclinical models in drug discovery and development 16 Summary 16 Introduction: Preclinical ADMET testing systems 17 The challenge: reducing drug attrition rates in preclinical screening 19 Importance of ADMET screening 22 Applying of ADMET to the drug discovery and development process 22 Importance of in vivo models 23 Established in vivo and in vitro ADMET tools to screen compounds 25 Toxicity and genotoxicity screening 26 Predicting toxicity with paracellular markers 27 In vitro ADMET screening in preclinical drug development 27 Advantages and disadvantages of conventional ADME screening tools in preclinical drug development 28 Oral absorption prediction 28 Metabolism prediction 29 In vivo ADMET animal models 30 Established ADMET study methods in animal models 32 Radiolabels 32 Cassette dosing 32 Semi-simultaneous dosing 33 Conclusion 34 Limitations of traditional in vitro and in vivo ADMET screening methods 34 New approaches to predict ADMET in preclinical development 36 Metabolomics 36 Advantages of metabolomics in drug discovery and development 37 Lead prioritization using metabolomics 37 Metabolomics and ADMET studies 37 Strengths and limitations of metabolomics for preclinical research 38 Metabolomics and "systems biology" - a unified approach to preclinical ADMET screening 40 Company focus: Merrimack Pharmaceuticals 41 Other emergent technologies used in preclinical drug discovery and development 42 Nanotechnologies in preclinical studies 42 Novel imaging systems 43 Preclinical research and recent multinational pharmaceutical company activities 44 Bayer AG and Nimbus Biotechnology 44 Pfizer/Johnson and Johnson and WuXi Pharma Tech 44 Roche 44 Sanofi-Aventis 45 UCB Pharma 45 Chapter 2 In vivo models in preclinical research 48 Summary 48 Vertebrate animal models in preclinical discovery and development 49 Assessment of predictive value of animal models 49 Rodent models 50 The need for improved small animal models 50 Humanized rodent models 51 Advantages and disadvantages of zebrafish models in preclinical research 52 Recent progress with vertebrate models 54 ADMET screens and zebrafish models: company developments and technologies 54 Discovery Genomics 54 Evotec AG 55 Phylonix 56 Summit 56 ZF Biolabs 57 Zygogen 58 ADMET screens in rodent models: selected company developments and technologies 59 Lexicon Pharmaceuticals 59 Taconic 59 Xenogen's (now part of Caliper) 61 Sigma-Aldrich 62 Invertebrate animal models in preclinical discovery and development 63 Drosophila melanogaster (fruit fly) 63 Aktogen 64 En Vivo Pharmaceuticals 66 Exelixis 67 Medros Pharmaceuticals 67 Caenorhadbitis elegans (nematode) 68 Novel in vivo/ex-vivo focus: Locusta migratoria (locust) 68 Chapter 3 In vitro models in preclinical research 72 Summary 72 Importance of in vitro models in preclinical toxicity testing 73 In vitro technologies for drug discovery and development 74 Recent company developments 74 Affymetrix 74 Beckman Coulter 75 Covance 75 Gene Logic 75 HemoGenix 76 Recent developments in drug transport and metabolism 76 Qualyst 76 Xenobiotic Laboratories 77 Progress in cell-based in vitro assays 77 Full ToC is available at: -- http://www.fastmr.com/ About Business Insights Business Insights appreciate the importance of accurate, up-to-date incisive market and company analysis and their aim therefore is to provide a single, off-the-shelf, objective source of data, analysis and market insight. Business Insights work in association with leading industry experts to produce a range of reports across a wide range of industry sectors. By working in association with so many experts they are able to provide clients with more incisive market analysis specific to the client's industry sector. No other market analysis company provides such focused and trusted market analysis, across such a wide range of industry sectors. View more research from Business Insights at http://www.fastmr.com/ About Fast Market Research Fast Market Research is an online aggregator and distributor of market research and business information. We represent the world's top research publishers and analysts and provide quick and easy access to the best competitive intelligence available. For more information about these or related research reports, please visit our website at http://www.fastmr.com or call us at 1.800.844.8156. End
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