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PROTAC technology has been in development for more than 20 years. The discovery of the first small molecule PROTAC and the subsequent small molecule E3 ligand, reported in 2008, greatly promoted the pursuit of PROTAC technology in academia and industry.

Dertrastuzumab is an antibody-drug conjugate (ADC) drug consisting of a humanized monoclonal antibody targeting HER2 attached to a topoisomerase 1 inhibitor payload via a tetrapeptide cleavable linker.

Hydrogels are composed of hydrophilic polymers, whose three-dimensional network structure can not only absorb a large amount of water, but also be used to carry drugs.

Antibody-drug conjugate (ADC) is one of the fastest growing fields in tumor therapy. So far, there are only 15 drugs on the market in the world.

Polyethylene (ethylene glycol) is a hydrophilic polymer that can have a very high water content when cross-linked into a network.

Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.

Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine agent in clinical studies, many advances have been made in the field of mRNA therapeutic technology after nearly 30 years of development.

In recent years, the scope and application scenarios of drug conjugates, including multiple concepts such as combination medication and precise drug delivery, have continued to expand, and a variety of emerging conjugation technology concepts have...

PROTACs (Proteolysis-targeting Chimeras), which was first proposed by Crews et al in 2001, can reduce protein levels rather than inhibit protein functions by taking advantage of the natural protein cleaning system in the body.

In recent years, targeted protein degraders have entered the mainstream of drug development at a very rapid rate.

Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.

Nmerous applications of PEGs have been reported in the scientific literature over the years.

Addgene, the nonprofit biorepository, today announced the appointment of Chonnettia Jones, Ph.D., as its new Executive Director. When Dr.

Just one dose of a new nanoparticle-based COVID-19 vaccine is enough to generate an immune response in animals, and the vaccines currently in clinical use are on track.

Addgene, the nonprofit biorepository, now produces and distributes ready-to-use recombinant antibodies.

Among adults with overweight or obesity, once-weekly subcutaneous semaglutide plus counseling for diet and physical activity results in significantly greater weight loss at 68 weeks than once-daily subcutaneous liraglutide, according to a study published.

3D printing (3DP) technology has been repurposed to apply to pharmaceutical development, in recent years it has been used to produce tablets of personalized dosage and combine several prescriptions into one tablet.

Antibody-Drug Conjugates (ADC) is a type of anticancer drug that links a drug to cancer-targeting antibodies. The antibody detects tumor-specific proteins expressed on cancer cells and directs the cytotoxic anticancer drug towards the cancer cell.

A unique antibody drug conjugate (ADC), which delivers a high dose of a cancer-killing drug to tumor cells through a targeted antibody, has been found in a global phase 3 clinical study to nearly double the survival time of patients with refractory...

The coronavirus pandemic has made vaccines from Pfizer/BioNTech and Moderna and the mRNA technology that they use into household names.

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing...

The FDA amended the emergency use authorizations (EUAs) for both the Pfizer-BioNTech & the Moderna COVID-19 Vaccine to allow for the use of an additional dose in certain immunocompromised individuals.

Unlike common diseases such as colds and coughs, cancer is a more significant disease with a high mortality rate. Globally, cancer causes the second largest number of deaths after cardiovascular disease.

Monodisperse PEG products usually are organic compounds with a molecular weight of less than 1000. Monodispersed PEG linkers are pure compounds with a single molecular weight.