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Follow on Google News | Education on the Role of Liquid Biopsy in Lung Cancer Management Aims to Improve Patient MortalityBy: DKBmed With approximately 236,000 new cases diagnosed alone in the United States in 2021, lung cancer is the second most diagnosed cancer globally after breast cancer. Although 5-year survival rates exceed 60% for patient subsets whose cancers were diagnosed in earlier stages, a majority of lung cancer cases are diagnosed in advanced stages. In this setting, where the cancer has metastasized to the brain and bones, between 3% and 9% of patients live past 5 years. To achieve optimal outcomes, the National Comprehensive Cancer Network stresses the importance of molecular profiling of the tumor using biomarkers detected with biopsies. Among the most exciting advances in the management of advanced lung cancer is the liquid biopsy, which detects circulating tumor DNA and other biomarkers shaded in the bloodstream. Liquid biopsy is a versatile tool that enables clinicians to noninvasively identify the most suitable therapy for each individual patient and monitor the response to treatments. "Traditional biopsies can be costly, invasive, and ultimately infeasible for many patients with advanced, metastatic lung cancer who have poor performance status. As more targeted treatments gain approval and complicate clinical decision-making, oncology care providers will need greater familiarity with next-generation tools that allow us to realize the fullest potential of precision oncology. A wider adoption of liquid biopsy, namely cell-free DNA analysis, is eagerly awaited," notes Christian Rolfo, MD, PhD, president of the International Society of Liquid Biopsy and deputy chair of the Educational Committee at the International Association for the Study of Lung Cancer. In Oncology Innovations:
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