Research Progress of Tetrahydrocurcumin

By: Hunan Huateng Pharmaceutical Co. Ltd.
CHANGSHA, China - Feb. 20, 2023 - PRLog -- Tetrahydrocurcumin (THC) has obvious antioxidant effect and has been used as a natural functional whitening raw material for cosmetics research and development.

So far, studies have found that it has anti-metastasis and anticancer activities, antioxidant, free radical scavenging, hypoglycemic, hypolipidemic and other pharmacological activities. In addition, our previous study also found that tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases, and has a wide range of application prospects.

1.Hypoglycemic Effect

Murugan P et al. induced type 2 diabetes mouse model with streptozocin, and then treated with tetrahydrocurcumin. The results showed that tetrahydrocurcumin could significantly reduce the blood sugar of diabetic mice and significantly improve insulin level, and the hypoglycemic effect of tetrahydrocurcumin on diabetic mice was even stronger than curcumin itself.

2.Anti-oxidative Stress Effect

Murugan P et al. used niacinamide to induce diabetic rats, and the results showed that tetrahydrocurcumin could significantly improve the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione - S-transferase, reduced glutathione, vitamin C and vitamin E in the liver and kidney of diabetic rats. These results indicated that tetrahydrocurcumin could protect and prevent cell membrane damage caused by lipid peroxidation.

3.Anti-fatty Liver Effect

Pan Xuefeng et al. studied the anti-fatty liver effect of tetrahydrocurcumin on human liver cell line L02 induced by oleic acid in vitro and in vitro, and the results showed that tetrahydrocurcumin could reduce the lipid droplets in human liver cell line L02 cells. In vivo experimental results of mice showed that tetrahydrocurcumin could reduce liver index, lipid, ALT, AST, and improve liver pathophysiology, and showed an obvious dose-effect relationship.

4.Hypolipidemic Effect

Karthikesan K et al. confirmed that tetrahydrocurcumin has a hypolipidemic effect on experimental diabetic rats induced by streptohomycin (STZ) -niacinamide (NA), and can restore the regulatory enzymes involved in lipid and lipoprotein metabolism, and its mechanism may be related to the increase of insulin secretion and antioxidant activity.

5.Effect of Lowering Blood Pressure

After the success of the model, rats were treated with different doses of tetrahydrocurcumin, which showed obvious blood-pressure lowering effect 2 weeks after administration. And showed a dose-dependent relationship. There was no significant effect on blood pressure in the normal group.

6.Anticancer Effect

Lai C S et al. regularly injected azoxymethane subcutaneously into colon cancer mice to induce colon cancer in mice, then continued to feed curcumin and tetrahydrocurcumin, and evaluated the tumor after the experiment. The results showed that both curcumin and tetrahydrocurcumin could inhibit the formation of degenerative crypt foci and polyps, but tetrahydrocurcumin showed a better inhibitory effect.

Huateng Pharma is a leading pharmaceutical intermediates supplier that can supply Tetrahydrocurcumin ( in large quantities with reasonable price.

Source:Hunan Huateng Pharmaceutical Co. Ltd.
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