NATCO Announces Clinical Trial Results Demonstrating Positive Effects of Persimonal™ on Cardiovascular Health

The study, "The effects of a persimmon leaf oral supplement (Persimonal™) on cardiovascular health: a randomized, double-blinded, placebo-controlled study," published in HealthMED, supported use of persimmon leaf extract (Persimonal™) orally as a dietary supplement for the purpose of cardiovascular health improvement when used daily.
By: NATCO, Inc.
TEMECULA, Calif. - Feb. 14, 2023 - PRLog -- Nutraceuticals & Agriceuticals Technology Company (NATCO), developer of high-end pharmaceutical food-grade botanical ingredients, announced today the results of a randomized, double-blinded, placebo-controlled study of the effect of a persimmon leaf oral supplement (Persimonal™) on participants' cardiovascular health, particularly blood pressure values and lipid profiles.

Persimonal™ is an advanced botanical extract of persimmon leaves made up of a highly therapeutic compound of flavonoids, polyphenols, tannins, terpenoids, organic acids, and carotenoids, naturally sourced from the leaves of Diospyros kaki Thumb (Persimmon).  The polyphenolic compounds of persimmon leaves are known to be anti-oxidative, anti-inflammatory, anti-carcinogenic, and cardioprotective, though the positive effect of Persimonal™ on blood pressure values and lipid profiles, specifically, were confirmed with this study.

Results showed that participants who were treated with Persimonal™ oral supplement had statistically significant reductions in mean blood pressure values compared to baseline values, and significant reduction in the total blood cholesterol values, after 180 days of daily use.  The data supports the view that Persimonal™ may be administered to patients as a potential cardiovascular dietary supplement.

"We are pleased to announce these positive results of Persimonal™ to reduce blood pressure and lipids in the blood, further expanding our excitement about this high-quality product.  It is no wonder persimmon leaves have been an essential part of traditional medicine in Asia for centuries," said Abdul Alkayali, Cofounder and Executive Vice President of NATCO.


Nutraceuticals & Agriceuticals Technology Company (NATCO) is a renowned and trusted industry leader founded in California by a group of experts with more than 30 years of experience in nutritional supplements. NATCO produces the finest nutritional botanical ingredients to be found in nature, and offering select ingredients that support cell and tissue health throughout the body. NATCO specializes in quality botanicals such as Persimmon Leaf Extract, Organic Monk Fruit Extract, and Citrus Fruit Extract, as well as broad, cutting-edge nutraceuticals that are recognized for their healing properties and health benefits.

Learn more at

Contact NATCO :  Email:; Phone:  949-554-8853


Bagatela, Bianca, et al.  "The effects of a persimmon leaf oral supplement (Persimonal® ) on cardiovascular health: a randomized, double-blinded, placebo-controlled study."   HealthMED, Vol. 17, Number 1, 2023.

Abdul Alkayali

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