Potential Applications of mRNA Technology: Ophthalmology Could Be A Breakthrough

CHANGSHA, China - Aug. 23, 2022 - PRLog -- Since the COVID-19 epidemic, Pfizer and Moderna have used mRNA technology in a vaccine to help humans fight COVID-19.

In mRNA technology, mRNA that can encode a specific protein is delivered directly into human cells so that the cells translate the mRNA to express the target protein, either to activate the immune system's response to the protein (which is the mechanism of mRNA vaccines), or to replenish disease-causing proteins that the body lacks, and so on.

Since mRNA technology can enable cells to produce any information, it has a broad application prospect, including antiviral, tumor, protein deficiency/error diseases, and other types of diseases.

Virus vaccines & Tumor vaccines

In fact, mRNA technology is currently best known for its use in vaccines.

Based on the success of the COVID-19 mRNA vaccine, mRNA projects targeting various viral infections have also been launched, mostly based on the same basic principles.

mRNA is in the direction of vaccines, in addition to antiviral vaccines, there is also a type of vaccine - tumor vaccines.

mRNA therapy

The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Under the assumption of mRNA therapy, many diseases can be treated.

Therapeutic applications include:

(1) Protein replacement to restore the function of a single protein for rare single-gene diseases;

(2) Cell reprogramming, mRNA can regulate cell behavior by expressing transcription or growth factors;

(3) Immunotherapy, in which mRNA-encoded transcripts elicit specific immune responses against target cells.

For mRNA therapy, low immunogenicity, high stability, and efficient translation are required by design. However, the expression of mRNA vaccines is transient and will degrade over time.

Secondly, the delivery of mRNA is still dominated by lipid nanoparticles (LNPs) (https://us.huatengsci.com/news/show/1579.html). Lipid Nanoparticle (LNP) is currently the dominant delivery system. They are often used in vaccines due to their relatively easy uptake by antigen-presenting cells. The three major mRNA vaccine giants Moderna, CureVac and BioNTech are currently using LNP delivery technology for their COVID-19 vaccines.

In the field of mRNA therapy, CureVac Chief Financial Officer Pierre Kemula said in an interview that the eye may be a good breakthrough, with an independent treatment window and a safer dose.

Conclusion

As a new technology, mRNA has made breakthroughs in the treatment of infectious diseases and tumors in a short time. mRNA technology still has many areas to be developed, including various application areas and disease treatment. As science continues to advance, mRNA technology is expected to improve more disease treatments in the future.

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