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Dimitri Krainc Northwestern Feinberg School of Medicine: Elucidating Parkinson's Disease
Parkinson's disease is a complex illness. Curative treatment is still out of reach. Recent advances have powered a new, deeper understanding of the disease that could reveal the last pieces of this decades-long puzzle.
By: Our Featured
According to findings published in Science, dysfunction of these organelles leads to an accumulation of toxic oxidized dopamine that contributes to preferential degeneration of dopaminergic neurons in PD.
Dimitri Krainc, MD, Ph.D., the Aaron Montgomery Ward Professor and chairman of the Ken and Ruth Davee Department of Neurology, published recent findings in Science.
A study from the Krainc laboratory published in Nature showed that mitochondria and lysosomes form direct contacts, and recent work published in Nature Communications showed that these contacts are disrupted in PD. Based on these findings, the Krainc laboratory used patient-derived neurons to develop and test a new strategy to treat Parkinson's disease by mitigating the effects of dysfunctional lysosomes and mitochondria, as detailed in a study published in Science Translational Medicine.
"These key pathological features of PD were only seen in human neurons and not in mouse models, further emphasizing the value of patient-derived neurons for drug development in Parkinson's disease," said Dimitri Krainc, who is also director of the Simpson Querrey Center for Neurogenetics.
To learn more about Dimitri Krainc, please visit https://dimitrikrainc.ourfeatured.com