Nature Article Cites Cleanascite™ for Lipid Influences in Tumor-associated Macrophages

MONMOUTH JUNCTION, N.J. - Nov. 22, 2021 - PRLog -- Biotech Support Group reports on a research article describing the simplicity and efficiency of their lipid depletion technology to determine the influence of lipid composition and saturation on the ER membrane of macrophages in tumors. The citation is:

Di Conza, Giusy, et al. "Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity (https://www.nature.com/articles/s41590-021-01047-4)." Nature immunology (2021): 1-13.

Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues. However, the underlying mechanisms by which tumor cells instruct TAM behavior remain elusive. The investigators here uncover that tumor-cell-derived glucosylceramide stimulated unconventional endoplasmic reticulum (ER) stress responses by inducing reshuffling of lipid composition and saturation on the ER membrane in macrophages.

As part of the study, a comparison of culture media (CM) with and without lipids (woLip) was made. The article states "To generate culture media without lipids, …CM was treated with Cleanascite according to the manufacturer's instructions.". The authors uncover the unexpected roles of tumor-cell-produced lipids that simultaneously orchestrate macrophage polarization and survival in tumors and reveal therapeutic targets for sustaining host antitumor immunity.

"Cleanascite™ is an aqueous suspension product without harmful solvents, or any other non-specific cytotoxic effects. As you see from this data, it ultimately helps researchers investigate how lipids impart characteristic changes in cells. This article exemplifies such utility." states Swapan Roy, Ph.D., President and Founder of Biotech Support Group

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About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for Covid-19 and cancer patients. For more information, go to http://www.biotechsupportgroup.com (http://www.biotechsupportgroup.com/biotechsupportgroup.com).

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