p53 Prions - Novel Biomarker for Circulating Tumor Cells

WIENER NEUSTADT, Austria - Sept. 23, 2021 - PRLog -- -       p53 aggregates frequently present in circulating tumor cells (CTC)

-       Novel tests by OncoLab (Austria) identify cancer cells via p53 prions

-       Kits for use with tissues, cells, and blood available

-       OncoLab's range of IF and PCR-based circulating rare cell (CRC) detection kits extended

Wiener Neustadt (Austria), September 22^nd, 2021. A patent-pending new technology allows more reliable identification of circulating tumor cells (CTC). The technology is based on the identification of p53 aggregates ("p53 prions") using Blood-based Biopsy tests (BBB) developed by OncoLab GmbH, Austria. p53 is a well-known tumor suppressor protein. Mutations of the gene can cause prion-like aggregation of p53-proteins. OncoLab has developed tests for amplified immuno-labeling of these aggregates using proprietary technology of Navinci Diagnostics AB, the Swedish specialist for visualizing proteins and their protein-protein interactions and post-translational modifications.

Besides p53 aggregates the OncoLab's CTC test "nPAC^TM AMYLOplex^TM CTC-p53" also detects known CTC markers (several cytokeratins) as well as leucocyte markers. It is based on immunofluorescence, a method that allows a direct identification of CTCs and provides information about the morphology and numbers of CTCs. Immunofluorescence staining is also used in OncoLab's "nPAC^TM CRC IF" series of tests that is offered in collaboration with US-based AxonDx, LLC.

About OncoLab Diagnostics GmbH (September 2021)

OncoLab develops, manufactures and distributes innovative and precise diagnostic tests with a focus on Blood-based Biopsy tests. Products are available for detecting circulating tumor, endothelial and stromal cells as well as immune cells. The company is certified according to ISO 9001:2015 and ISO 13485:2016 and member of the International Society of Liquid Biopsy (ISLB) and the European Liquid Biopsy Society (ELBS).

https://www.oncolab.at