Xuanzhu and SignalChem Lifesciences Announce Licensing Agreement for SLC-391 in Greater China

BEIJING - Sept. 23, 2021 - PRLog -- Beijing, China and Richmond, British Columbia, Canada -- Xuanzhu Biopharmaceutical Co., Ltd. ("Xuanzhu") and SignalChem Lifesciences Corporation ("SignalChem") announced today that they have entered into an exclusive collaboration and licensing agreement for the clinical development and commercialization of SLC-391, a potent and selective AXL targeting inhibitor, in the Greater China region.

Under the terms of the agreement, Xuanzhu will pay to SignalChem an upfront fee of thirteen million US dollars (US$13,000,000). Additional development milestones and royalties have also been committed. The exclusive rights for SLC-391 for the field of oncology is for the Greater China region.

About SLC-391

SLC-391 is a potent, highly selective and orally bioavailable small molecule AXL inhibitor. Preclinical investigational data shows SLC-391 is a superior AXL inhibitor and has the potential to become a first-in-class inhibitor. Phase I clinical study is currently underway in Canada. SignalChem has established a collaboration with Merck (MSD) to evaluate the efficacy of SLC-391 in combination with Keytruda® (pembrolizumab) for the treatment of advanced non-small cell lung cancer (NSCLC). In pre-clinical studies, SLC-391 demonstrated strong efficacy as a single agent or in combination with other approved drugs in multiple animal models for cancer. SLC-391 will be developed to undisclosed cancer indications as a single agent or in combination with other therapies.

About Xuanzhu

Xuanzhu Biopharmaceutical Co., Ltd., a subsidiary of Sihuan Pharmaceutical Holdings Group Ltd., is an innovative biopharmaceutical company rooted in China with a global perspective, focusing on tumors, metabolic diseases, infections, and other fields. It has a layout of the entire industry chain from drug discovery, preclinical research, clinical development, and production commercialization. Our strengths reside in our detailed knowledge and expertise in the clinical development and regulatory approval processes in China. Xuanzhu has a clinical and regulatory team of over 300 people bringing expertise from numerous multinational pharmaceutical companies including J&J, Lilly, Merck, Novartis, Pfizer, and Roche. This combined with the most extensive sales and marketing capability in China, places Xuanzhu as the premier partner for those companies with innovative assets desiring to enter the China domestic market.

About SignalChem Lifesciences Corporation

SignalChem Lifesciences Corporation, headquartered in Richmond, British Columbia, Canada, is a clinical-stage company developing novel targeted therapies for oncology. Its unique business model has been built upon four important pillars: Drug Discovery and Development, the Bioreagents and Research Services business, In-Vitro Diagnostic Reagent Development and Plant Biosynthesis Systems. We at SignalChem are a group of scientists with extraordinary expertise and experience in protein engineering and drug discovery who are working together cohesively to provide the best products and services to our customers around the world and to maximize the efficiency of our own drug discovery efforts.

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