Creative Biostructure Provides a Wide Range of Protein Evolution Services

SHIRLEY, N.Y. - Sept. 2, 2021 - PRLog -- Creative Biostructure, a biotechnology company that specialized in providing cost-effective services to both academia and biotech industries in the field of structural biology and membrane protein technologies, now provides a wide range of protein evolution services (https://www.creative-biostructure.com/protein-evolution-services-338.htm) to help promote its customers' research process.

Since changes in protein sequence respond to changes in DNA sequence, protein evolution is closely associated with changes and selection of DNA polymorphisms and mutations. So far, great efforts to understand protein evolution have targeted domains, i.e., the formation of independent folding units of modern proteins. The most powerful tools for characterizing protein sequences are protein sequence comparison and sequence similarity search.

Scientists at Creative Biostructure are able to address gene/function issues through bioinformatics and experimental approaches. Strikingly, the company can use computational processes to estimate new domain types or detect new instances of known domains in poorly characterized proteins. On the other hand, they can complement the bioinformatics screening of protein function using appropriate experimental screens and validate some bioinformatics findings. Protein evolutionary rates can be obtained by calculating the evolutionary distance between sequences originating from a common ancestor. The evolutionary distance was measured as the number of substitutions per site. To estimate the distance, it is highly desirable to identify the ortholog proteins and to align those amino acid positions from the same ancestral site.

Protein evolution services at Creative Biostructure include:

• Consultation to find the best strategy to evolve the protein (random, rational, or combined approach)
• Cloning & expression using our proprietary cloning technology and production strains
• Sophisticated high throughput screening assay development for desired protein activities and their applications
• Design, generation and screening of the mutant libraries
• Optional: purification and characterization of best performing variants (kinetic properties, selectivity, stability etc.

According to the official speaker from Creative Biostructure, their optimal strategies for protein evolution services include: Library design and construction, Phylogenetic tree construction, De novo Design (https://www.creative-biostructure.com/De-Novo-Design-17.htm), Directed Evolution and Rational Design.

"Over the years, we have been actively working on the characterization of proteins using a variety of techniques, as well as the engineering of proteins (https://www.creative-biostructure.com/protein-engineering...) for various applications. The extensive experience gained in those areas enables us to provide customized services in a timely and cost-effective manner." Said Joanna, the chief marketing staff at Creative Biostructure.

For more information about the protein evolution services offered by Creative Biostructure, please visit https://www.creative-biostructure.com/protein-evolution-services-338.htm.