Co-innovation of Bioink and Powerful 2-Photon Bio-Printer Allows 3D-Printing with Living Cells

VIENNA - April 13, 2021 - PRLog -- The combination of a 2-Photon 3D-printer with an innovative hydrogel-based bioink allows the direct printing of 3D structures containing living cells at both the meso- and microscale. Developed by UpNano GmbH (Vienna, Austria), the NanoOne Bio is a printer based on the successful NanoOne range of laser-powered 2-Photon 3D-printers that are able to build structures across 12 orders of magnitude. The new hydrogel has been developed with Xpect INX (Ghent, Belgium), a spin-off in foundation specialized in the development of biocompatible materials for the 3D-(bio-)printing industry. It is the only commercially available resin that allows embedding living cells straight from a culture plate within highly precise 3D-printed structures for biological applications.

Two-dimensional cell cultures have been the standard in pharmaceutical preclinical R&D and in biomedical research in general, for many decades. However, growing evidence demonstrates that these models poorly represent the cellular interaction at the 3D level in living systems. Therefore, drug development based on 2D systems is often misguided, resulting in billions of dollars of unfruitful R&D costs. So far, building complex and highly precise 3D structures with embedded living cells has been hampered by lack of suitable materials and printing systems. Thanks to the joint development of a novel hydrogel-based Bioink by Xpect INX and UpNano in combination with the new printing model by UpNano this endeavor has now turned into reality.

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