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MMP-13 Inhibitor Screening Kit (Fluorometric)
A quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of MMP-13.
By: BioVision, Inc.
Additionally, it cleaves other ECM molecules including fibronectin, aggrecan, osteonectin etc. MMP-13 plays a major role in ECM remodeling during fetal bone development, post-natal bone remodeling, tissue remodeling etc. It is overexpressed in numerous pathological conditions including rheumatoid arthritis, osteoarthritis, atherosclerosis, aortic aneurysms, cancer etc. Thus, developing and screening of selective MMP-13 inhibitors is under intensive investigation for therapeutic intervention.
BioVision's MMP-13 Inhibitor Screening Assay Kit provides a quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of MMP-13. In this assay, MMP-13 hydrolyzes a FRET-based MMP-13 substrate and releases unquenched by the catalysis of fluorescent group, Mca, which is detected fluorometrically at Ex/Em = 325/393 nm. A potent, specific MMP-13 inhibitor is also included in the kit.
Figure: Inhibition of MMP-13 activity by the MMP-13 inhibitor (BioVision Cat. # 9607). IC50 was calculated to be 100.4 nM. Assay was performed following the kit protocol.
For more information on this Assay Kit Cat# K2067, Visit: https://bit.ly/
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