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Furin Inhibitor Screening Kit (Fluorometric)
A quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of Furin.
By: BioVision, Inc.
In addition to processing precursor proteins, Furin is utilized by numerous viral and bacterial pathogens for enhancing their virulence and spread. For example, the envelope protein of viruses such as HIV, influenza, several filoviruses including Ebola and Marburg virus, and the spike protein of SARS-CoV-2 must be cleaved by furin or furin-like proteases to become fully functional. Because of the role of Furin in many cellular processes and diseases, it is emerging as a potential therapeutic target for infectious and non-infectious diseases.
BioVision's Furin Inhibitor Screening Kit provides a quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of Furin. In this assay, Furin cleaves a fluorescent peptidyl substrate and generates a fluorescence signal, which is detected at Ex/Em = 360/460 nm. A potent, specific Furin inhibitor is also included in the kit.
Figure: Inhibition of Furin activity by Furin inhibitor. IC50 was calculated to be 73.7 nM. Assay was performed following the kit protocol.
For more information on this Assay Kit Cat# K2069, Visit: https://bit.ly/
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