MOBILion and International Research Team are Awarded Grant from The Michael J. Fox Foundation
By: MOBILion Systems
The assembled international team brings together the diverse expertise needed to dissect the metabolic glycosphingolipid map in Parkinson's disease (PD). The team includes Dr. Kim Ekroos of Lipidomics Consulting Ltd., a pioneering subject matter expert in the field of lipidomics, the research group of Dr. Shane Ellis at the University of Wollongong in Australia; Dr. Ron Heeren from the Maastricht Multi Modal Molecular Imaging Institute (M4I), a world-leading institute in lipid Mass Spectrometry Imaging; Dr. Nathan Hatcher, a Principal Scientist with the Department of Neuroscience at Merck.
The project is funded by a grant from The Michael J. Fox Foundation and its partner the Shake It Up Australia Foundation and builds on several technical developments made by the group at M4I in the fields of mass spectrometry imaging and lipid analysis. This research will include use of MOBILion's Structures for Lossless Ion Mobility (SLIM)-based High-Resolution Ion Mobility (HRIM) instrument to identify alterations in the metabolism of selective glycosphingolipids (GSLs) in specific brain regions that contribute to early Parkinson's onset and accelerated progression rates.
PD affects more than 6 million people worldwide. Glycosphingolipids are natural cellular fats and part of the PD epidemiology. They are components of cellular membranes that fulfill multiple functional roles, from cell structure and transport to signalling. However, the contribution of glycosphingolipids to PD is not fully understood.
"We are excited to apply MOBILion's high resolution separations technology to advance the characterization of glycosphingolipids,"
"Our approach is a game-changer,"
MOBILion has partnered with Agilent Technologies Inc. to integrate their HRIM separations technology with Agilent's Q-TOF mass spectrometry platform as the company's first commercial product offering, to be fully commercialized in 2021. Members of the above research group have pre-commercial use of the MOBILion High-Resolution Ion Mobility instrument.
For more information on the above visit http://www.mobilionsystems.com.