Cleanascite™ Cited in the Preparation of Monoclonal Antibodies
By: Biotech Support Group
Collecting and Storing Hybridoma Tissue Culture Supernatants
Cold Spring Harb Protoc 2020.
© 2020 Cold Spring Harbor Laboratory Press (http://cshprotocols.cshlp.org/
For most immunochemical methods, tissue culture supernatants will be the most useful source of monoclonal antibodies. The supernatants are not contaminated with high levels of other antibodies, and the concentration is high enough for most assays if used undiluted. Procedures for collecting tissue culture supernatants are described. In the Troubleshooting section, the chapter states: "Problem (Step 7): A precipitate of lipids and/or cryoproteins has formed.
Solution: This may be produced by long-term storage at 4°C. These precipitates can be removed …using Cleanascite (Biotech Support Group; X2555) for clarification."
"With the cost and complexity of producing pure monoclonal antibodies, it is essential to have methods that maintain high yields. Here is another citation for the use of Cleanascite™
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About Biotech Support Group LLC
Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™
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