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Huateng Pharma Develpoed Kinds Of Intermediates For Carfilzomib
Carfilzomib (marketed under the trade name Kyprolis, developed by Onyx Pharmaceuticals) is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin.
By: Huateng Pharm
Carfilzomib is derived from epoxomicin, a natural product that was shown by the laboratory of Craig Crews at Yale University to inhibit the proteasome. The Crews laboratory subsequently invented a more specific derivative of epoxomicin named YU101, which was licensed to Proteolix, Inc. Scientists at Proteolix invented a new, distinct compound that had potential use as a drug in humans, known as carfilzomib. Proteolix advanced carfilzomib to multiple Phase 1 and 2 clinical trials, including a pivotal phase 2 clinical trial designed to seek accelerated approval. Clinical trials for carfilzomib continue under Onyx Pharmaceuticals, which acquired Proteolix in 2009.
Carfilzomib covalently irreversibly binds to and inhibits the chymotrypsin-
Huateng Pharma develpoed several kinds of intermediates for Carfilzomib with high quality & fast shipping. We are able to provide the services of Anti-Cancer intermediates' process development and scale-up production with capacities varying from gram to kilograms and multi tons.
Today I want to introdude two kinds of intermediates for Carfilzomib from Huateng Pharma.
Product name: 1-Pentanone,2-
CAS NO.: 247068-85-5
Catalog ID: 98534
Molecular formula: C9H17NO2.C2Hf3O2
Molecular weight: 285.26
Product name: (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-
CAS NO.: 868539-96-2
Catalog ID: 99702
Molecular formula: C31H43N3O6
Molecular weight: 553.696
Company: Hunan Huateng Pharmaceutical Co. Ltd.
Address: Lugu Business Plaza E1, Yuelu District, Changsha City, Hunan Province, P.R. China
Zip code: 410205
Telephone: +86 731 89916275
Fax: +86 0731-82251112-
About us: Human Huateng Pharmaceutical Co., Ltd. is a leading and professional manufacturer which can provide PEG derivatives, biochemical reagents, pharmaceutical intermediates, APIs, Vitamin D Derivatives and targeted anti-tumor drugs.
Hunan Huateng Pharmaceutical Co. Ltd.