Research Article Cites Cleanascite™ In Regulation of Hepatitis B Virus in vitro

By: Biotech Support Group
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* Hepatitis B Virus

* Biotech

* Monmouth Junction - New Jersey - US

* Reports

MONMOUTH JUNCTION, N.J. - April 21, 2019 - PRLog -- Biotech Support Group reports on a recent research article describing the simplicity and efficiency of their lipid clearance sample preparation technology for determining variability in the in vitro regulation of Hepatitis B virus (HBV). The citation is:

Lee, Hong-Jai, et al. "Regulatory effect of humoral milieu on the viral DNA and surface antigen expression of hepatitis B virus (HBV) in vitro. (" Molecular & Cellular Toxicology 15.2 (2019): 123-128.

The investigations explored if humoral milieu such as serum or culture media, and its constituents, and pH would regulate the viral DNA and surface antigen expression of HBV in vitro. Furthermore, lipid removal analysis showed decreased level of HBV DNA and surface antigen expression in human and mouse serum. The article states "To evaluate the lipid exposure status within lipid bilayer, Cleanascite (Biotech Support Group) was added to HBV mixtures in the human serum, mouse serum, or DMEM, and the HBsAg and HBV DNA were evaluated. … we examined the virus-lipid interaction in non-host milieu, and compared the interaction between in host and non-host milieu. The levels of HBsAg and HBV DNA were significantly decreased with lipid removal by Cleanascite in mouse serum rather than human serum". The authors' concluded that humoral lipid might confer protection to virion against toxicants or hostile interaction with humoral components.

"This article is another example for the value of Cleanascite™ as a serum delipidation reagent so as to understand the effects of lipids on the viability of viruses. It fits into many other applications that show its utility in generating in vitro cell response information." states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification, at

For a complete report on Cleanascite™ use in cell response applications, go to

About Biotech Support Group LLC

Converging with cultural and technological disruptions forthcoming in healthcare, Biotech Support Group develops methods for cost effective and efficient sample prep essential for these expanding markets. Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include: AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to


Matthew Kuruc 732-274-2866,

Biotech Support Group LLC
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