Breaking News! The artificial sweetener Sucralose is metabolized and accumulates in fat tissue
A study just published in the "Journal of Toxicology and Environmental Health, Part A," contradicts claims by the chemical sweetener industry that the artificial sweetener Sucralose is safe because it quickly passes through the body unchanged. It's now time to revisit the safety and regulatory status of this organochlorine artificial sweetener.
The artificial sweetener sucralose is metabolized and accumulates in fat tissue.
A study just published in the Journal of Toxicology and Environmental Health, Part A contradicts claims by the chemical sweetener industry that the artificial sweetener sucralose is safe because it quickly passes through the body unchanged. This claim was pivotal for gaining approval from regulatory agencies, including the US FDA for the addition of the chlorinated chemical sucralose to the food supply. However, an independent research laboratory with expertise in food quality and food safety testing, Avazyme Inc. in Durham, NC, in collaboration with researchers at North Carolina State University, have found that sucralose is indeed metabolized in the intestines. Furthermore, the research team also found that sucralose accumulates in fat tissue after prolonged exposure. Dr. Volker Bornemann and his team at Avazyme have many years of experience in studying xenobiotic metabolism and utilized state of the art ultra high-performance liquid chromatography (UHPLC) and mass spectrometry to analyze fecal, urine, and fat samples from test specimens, who were exposed to sucralose daily for an extended period of time. Dr. Bornemann noted: "At first, we did not see any difference to what other researchers had found before, when we replicated their methodology. Only after we used a different, more suitable extraction methodology and study design did we find that sucralose had actually been metabolized to a significant extent, and also accumulated in the adipose fat over time. These sucralose metabolites had never been reported before." One of his co-authors, Dr. Susan Schiffman, concludes: "The important data and findings obtained in this study raise serious new concerns about food safety, and strongly demonstrate that it is now time to revisit the regulatory status of sucralose."
The entire study can be accessed at: https://www.tandfonline.com/
For additional information, please contact:
Dr Volker Bornemann e-mail: Media@Avazyme.com
Dr. Susan S. Schiffman e-mail: email@example.com
Intestinal Metabolism and Bioaccumulation of Sucralose in Adipose Tissue in the Rat
Volker Bornemann, Stephen C. Werness, Lauren Buslinger & Susan S. Schiffman
Received 30 May 2018, Accepted 16 Jul 2018, Published online: 21 Aug 2018
Sucralose paper link
The aim of this study was to (1) determine if the organochlorine artificial sweetener sucralose is metabolized in rat intestine with repeated dosing and (2) examine whether sucralose might bioaccumulate in rat adipose tissue. Sucralose was administered to 10 rats by gavage daily for 40 days at an average dosage of 80.4 mg/kg/day. The dosages were within the range utilized in historical toxicology studies submitted for regulatory approval in North America, Europe, and Asia. Feces and urine were collected individually from each animal for every 24-hr period during the 40-day dosing period. Analysis of the urine and fecal extracts by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/
AVAZYME, INC. Suzanne Bornemann
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