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Resurgence in the Use of Immune Checkpoint Inhibitors in Urothelial Carcinoma
"Recent developments in immune checkpoint inhibitors has resulted in dramatic shifts in the treatment paradigm of urothelial carcinoma," Says RNCOS
According to a new research report by RNCOS entitled, "Global Immune Checkpoint Inhibitors Market Outlook 2022", the emergence of immune checkpoint inhibitors as cancer immunotherapy has effectively built a new "highway" connecting the promise of oncologic translational research to progress in treating advanced urothelial cancer.
For the past few decades, there had been very little progress concerning the treatment options for patients with advanced urothelial cancer; however, clinical trials for Immune Checkpoint Inhibitors in recent years have shown significantly increased survival rates in patient with several types of malignant cancers. Following several successful trials, checkpoint inhibitors have emerged as FDA-approved options offering new hope to patients with advanced urothelial cancerand lung cancer.
In May 2016, the FDA approved the PD-L1 inhibitor atezolizumab (Tecentriq) as a treatment for patients with locally advanced or metastatic urothelial carcinoma (mUC) whose disease progressed during or after platinum-based chemotherapy, or within 12 months of receiving platinum-containing chemotherapy, either before or after surgery. The FDA granted an accelerated approval to the PD-1 inhibitor nivolumab (Opdivo) earlier this month as a treatment for patients with locally advanced unresectable or metastatic urothelial carcinoma
These Programmed death-1 checkpoint inhibitors facilitate tumour infiltration by T cells, resulting in targeted destruction by the immune system.
The studies presented in the last year demonstrated a revolutionary role for immune checkpoint inhibitors among patients with urothelial carcinoma. These findings, together with results from studies presented in the last year suggest that in the very near future immunotherapy will become a potential standard of care in the first-line setting for these patients.
With the increasing research & development in the sector, the market is expected to burgeon in the future.
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