Antibiotics UPDATE: 3 Discovery Projects to Tackle MDR Gram-Negative PathogensTim Opperman, Senior Research Scientist from Microbiotix, unveils new updates at Superbugs and Superdrugs USA 2017
By: SMi Group Understanding the translational link between animals and humans; navigating the pitfalls of early drug discovery; and evaluating the potential of immunotherapies will be a major focus, as will hearing from a selection of biotech and pharma companies currently undertaking clinical research. This will include case studies from Pfizer, MedImmune, Merck, Visterra and ContraFect. Event highlights will include a keynote presentation by Tim Opperman, Senior Research Scientist from Microbiotix. The talk will discuss advances in the three-prong approach taken by Microbiotix to address the problem of MDR Gram-negative pathogens. It is claimed that all three discovery projects have demonstrated efficacy in murine models of infection. Project 1 Virulance -Funded by CARB-X: Attendees will hear how a novel phenoxyacetamide series exhibits potent activity against type 3 secretion in Pseudomonas aeruginosa by targeting the assembled needle protein PscF. Project 2 Intrinsic Resistance: Microbiotix will explain how novel pyranopyridine inhibitors of RND-type efflux pump inhibitors exhibit broad spectrum activity against pathogens of the Enterobacteriaceae and favourable pharmacokinetics in mice. Project 3 Novel Essential Target: The talk will explore how a series of novel oxadiazoles bind to a unique site on the ribosome, resulting in potent inhibition of the essential non-stop ribosome rescue pathway in Gram-positive and negative pathogens, including MDR Neisseria gonorrhoeae and Francisella tularensis. These compounds exhibited potent antibacterial activity and oral bioavailability. A full speaker line-up and detailed agenda is available at www.superbugs- Superbugs & Superdrug's USA will take place on 13th and 14th November at the Renaissance Woodbridge Hotel in Iselin, New Jersey. --- end --- Contact Information: For media enquiries contact Teri Arri on Tel: +44 (0)20 7827 6162 / Email: tarri@smi-online.co.uk For all other enquires contact the team on Tel: +44 (0)20 7827 6000 or email events@smi-online.co.uk About SMi Group: Established since 1993, the SMi Group is a global event-production company that specializes in Business-to- Photos: https://www.prlog.org/ https://www.prlog.org/ End
Account Email Address Account Phone Number Disclaimer Report Abuse
|