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Follow on Google News | Progress Toward an HIV Cure Highlighted in Special Issue of AIDS Research & Human RetrovirusesLeonardo Calza and coauthors from University of Bologna (Italy), have shown that statins, which are commonly prescribed to lower blood lipid levels, can also significantly reduce the concentration of D-dimer, a marker of coagulation, and of two markers of inflammation known as interleukins (IL-8 and IL-10) in HIV-infected individuals. The anti-inflammatory properties of statins and their potential effects on blood clot formation could help reduce HIV-associated comorbidities such as cardiovascular disease. The researchers present their findings in the article entitled "Significant Decrease in Plasma Levels of D-Dimer, Interleukin- In the article "Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV (http://online.liebertpub.com/ Heather Grome and colleagues from Vanderbilt University Medical Center (Nashville, TN), report on the role that persistent T-cell and macrophage activation in HIV-infected adults on combination antiretroviral therapy may have on the function of arterial blood vessels. The effects of HIV-related chronic immune activation on the arterial lining and vascular smooth muscle may promote the development of atherosclerosis and plaque formation that can lead to cardiovascular disease. The researchers present measures of blood-based inflammatory and immune activation markers and the results of brachial artery flow-mediated dilation on ultrasound in the article entitled "Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV (http://online.liebertpub.com/ "It is becoming clear that although HIV-infected individuals can control the amount of virus in their system with antiviral treatments, there are still negative health consequences that look like premature aging, including cardiovascular disease and cognitive impairment," "These three papers and others in the Cure issue seek a better understanding of the cause of this accelerated aging. The Calza article suggests that taking statins, which reduce lipid levels, may be an effective treatment to reduce damaging inflammation in HIV-infected individuals taking appropriate antiviral therapy," Research reported by Grome et al. was supported by the National Institutes of Health under Award Numbers K23 100700, K24 AI65298, UL1 RR024975-01, and P30 AI110527. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. About the Journal AIDS Research and Human Retroviruses (http://www.liebertpub.com/ About the Publisher Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com/# Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 www.liebertpub.com Phone: End
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